Aftermath of Mark and Lexie's 'Grey's Anatomy' Love Story Unveiled

Mark Sloan discovered his person in Lexie Gray on Grey's Anatomy. He joined the show in 2006 as a plastic surgeon and best friend of Derek Shepherd, who later married Meredith Grey.

Mark was known for his playboy ways, frequently having casual relationships with interns and nurses at Seattle Grace Hospital. He engaged in a secret relationship with Meredith's half-sister, Lexie, in season 5. The couple became fan favorites before meeting a tragic end in a season 8 plane crash.

Eric Dane, who portrayed Mark, passed away in 2026 after battling ALS. He praised the show's handling of his character's departure in a 2017 interview with AOL.

Relationship Timeline:

Clandestine Hookups: Mark and Lexie began their relationship in season 5, despite warnings from others. Their hookups evolved into a more serious relationship, including cohabitation.

The Arrival of Sloan Sloan: In season 6, Mark's daughter Sloan arrived, pregnant, causing tension in his relationship with Lexie. They ultimately split due to differing views on starting a family.

Separate Lives: Lexie dated other characters while Mark remained mostly single. He briefly dated Callie Torres before reuniting with Lexie, only for their relationship to face challenges.

The Plane Crash: Mark and Lexie were involved in a plane crash in the season 8 finale. Lexie tragically passed away, holding Mark's hand, while he sustained injuries and later died at the hospital.

COVID-19 Fever Dream:

During Meredith's COVID-19-induced coma in season 17, she hallucinated deceased colleagues, including Mark and Lexie, encouraging her to wake up and reunite with her family.